1-Methylpseudouridine CAS 13860-38-3

Product Description:

Product Name: 1-Methylpseudouridine CAS NO: 13860-38-3

Synonyms:

5-(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl-1-methylpyrimidine-2,4-dione;

(-)-1-Methyl-5-( -D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione;

1-Methyl-5-( -D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione;

Chemical Physical Properties:

Appearance: White to pale pink powder

Assay : Greater than or equal to 99.0 percent

Density: 1.576g/cm3

Refractive Index: 1.618

N1-Methylpseudouridine is a modified nucleoside used for enhancing mRNA translation. Incorporation of N1-Methylpseudouridine into mRNA turns off the immune/eIF2 phosphorylation-dependent inhibition of translation, and increases ribosome pausing and density on the mRNA, thus dramatically facilitating the translation process. N1-Methylpseudouridine outperforms several other modified nucleosides (e.g. 5-Methylcytidine) and corresponding combinations in terms of translation capacity.

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